Re-Evaluating Causal Modeling with Mantel Tests in Landscape Genetics

Re-Evaluating Causal Modeling with Mantel Tests in Landscape Genetics

The predominant analytical approach to associate landscape patterns with gene flow processes is based on the association of cost distances with genetic distances between individuals. Mantel and partial Mantel tests have been the dominant statistical tools used to correlate cost distances and genetic distances in landscape genetics. However, the inherent high correlation among alternative resist...

Mantel test in population genetics

The comparison of genetic divergence or genetic distances, estimated by pairwise FST and related statistics, with geographical distances by Mantel test is one of the most popular approaches to evaluate spatial processes driving population structure. There have been, however, recent criticisms and discussions on the statistical performance of the Mantel test. Simultaneously, alternative framewor...

Causal model selection tests in systems genetics

We develop a novel hypothesis testing framework for causal inference among pairs of phenotypes in the context of segregating populations. Our model selection test extends Vuong’s test to the case of three misspecified models, to handle the full range of possible causal relationships among a pair of traits, namely, causal, reactive or independent models. The ability to properly address misspecif...

Dismantling the Mantel tests

1. Informatics and Mathematical Modelling Department, Technical University of Denmark, Copenhagen. Richard Petersens Plads, Bygning 305, 2800 Lyngby, Denmark. 2. Institut des Sciences de l’Évolution (UM2-CNRS-IRD), Université Montpellier 2, Place Eugène Bataillon, CC 065, Montpellier cedex 34095, France. Running title: Dismantling the Mantel tests. ∗ Corresponding author: [email protected] Word c...

Mantel Permutation Tests